Jan 2014 Transplant No 2
An allogenic transplant is a reduced intensity (mini allo) transplant using low dose chemo and low dose radiotherapy to condition and damp down the host’s immune system enough to be ready to receive new donor stem cells. It’s these new stem cells that create a new immune system and it’s this that works on the myeloma cells.
The graft versus myeloma is observed to be taking place by seeing some GVHD ( graft versus host disease).
Chris’s donor is a 41 year old male from Birmingham, we are able to contact him after 2 years.
March 2013 Transplant No 1
This is our blog which was set up to document Chris’s progress during and after his transplant. Dr Cavet said Chris’s myeloma was Tenacious so we looked up the definition and thought the description suited the owner of the myeloma too – game on –
persistent – tough – stubborn – dogged – obstinate
Chris is lucky enough to have a perfect match donor and will hopefully be having tandem transplants of an auto (own cells) followed by a mini allo (donor cells).
So what is this ? a bit of science for you.
He has already had chemotherapy to stablise his levels. This was then followed by the collection and storage of specific blood cells called stem cells, which are in the freezer till needed. Then very high doses of chemotherapy (melphalan) are given.
The aim of the high-dose therapy is toremove any residual myeloma cells. However, this treatment also kills normal healthy cells in the bone marrow. Therefore, after high-dose therapy, re-infusion of healthy stem cells is required which effectively ‘rescues’ the bone marrow, allowing blood cell production to continue.
During the time in hospital and for a good while after Chris’s immune system will be very compromised. Visitors to the hospital will be kept to a minimum and co-ordinated by me. Please do not show up at the hospital either. We would ask that if you have been ill or been near anyone who has been ill with a cough, cold, infection of any kind, that you don’t see us. This is extremely important for his recovery as the slightest bug or germ can be serious for him.